風邪に対する亜鉛投与は症状の期間短縮と重症度低下に有効

　感冒に対する亜鉛の投与は症状の持続期間短縮と重症度の低下に有効であると、米ウェイン州立大学のグループがJournal of Infectious Diseases（197: 795-802）に発表した。


Background Zinc lozenges have been used for treatment of the common cold; however, the results remain controversial. Methods. Fifty ambulatory volunteers were recruited within 24 h of developing symptoms of the common cold for a randomized, double-blind, placebo-controlled trial of zinc. Participants took 1 lozenge containing 13.3 mg of zinc (as zinc acetate) or placebo every 2-3 h while awake. The subjective scores for common cold symptoms were recorded daily. Plasma zinc, soluble interleukin (IL)-1 receptor antagonist (sIL-1ra), soluble tumor necrosis factor receptor 1, soluble vascular endothelial cell adhesion molecule, and soluble intercellular adhesion molecule (sICAM)-1 were assayed on days 1 and 5. Results. Compared with the placebo group, the zinc group had a shorter mean overall duration of cold (4.0 vs. 7.1 days; P<.0001 ) and shorter durations of cough (2.1 vs. 5.0 days; ) and nasal discharge (3.0 vs. 4.5 days). Blinding of subjects was adequate, and adverse effects were comparable in the 2 groups. Symptom severity scores were decreased significantly in the zinc group. Mean changes in plasma levels of zinc, sIL-1ra, and ICAM-1 differed significantly between groups.Conclusion. Administration of zinc lozenges was associated with reduced duration and severity of cold symptoms. We related the improvement in cold symptoms to the antioxidant and anti-inflammatory properties of zinc.

【アブストラクト：Catsduke訳】
［背景］
　亜鉛トローチは感冒の治療に用いられているが、その結果については未だに諸説がある。
［方法］
　感冒の症状発現から24時間以内の外来患者ボランティア50名による、亜鉛の無作為化・二重盲験・プラセボ対象試験。参加者は酢酸亜鉛13.3mg含有トローチまたはプラセボを起きている間は２〜３時間ごとに１錠服用し、感冒症状の主観的スコアを毎日記録した。血清中亜鉛、可溶性のIL-1レセプター拮抗剤 (sIL-1ra)、可溶性の腫瘍壊死因子レセプター1、可溶性の血管内皮細胞接着分子、可溶性の細胞間接着分子 (sICAM)-1が、１日めから５日まで定量された。

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タグ：感冒　かぜ　亜鉛の投与